What is Liposomal CBD?

CBD, short for Cannabidiol, is a multipurpose cannabinoid with excellent anti-inflammatory, analgesic and anti-anxiety features. Unfortunately, it can be a bit challenging for the body to utilise these helpful qualities. The molecular structure of CBD makes its absorption in the body more difficult compared to other cannabinoids like the THC.

Luckily, the liposomal CBD helps ease the absorption of CBD. It surrounds the cannabinoid (CBD), with an element that can easily be absorbed in the body. This unique element makes it easy for the body to utilize CBD’s properties, thus increasing its effectiveness. In addition, you consume less CBD and get more results.

What does Liposomal mean?

Liposomes are minute scopes surrounding a medicine or nutrient like CBD, which supports its assimilation in the body. The name liposome originated from Greek. It constitutes of Greek words lipos, which means fat and soma meaning body.

According to Dr Adie Rae, an expert in medicinal cannabis and CBD, a liposome is simply a sphere-like package that is used to pack a drug. Liposomes are made from phospholipids that are the same molecules in the body’s cell membrane. Phospholipids help in drug absorption as well as preventing the breakdown of a drug in the digestive region. This unique feature make CBD more effective.

Liposomes were initially discovered in the 1960s. Since then, there have been developments to improve the effectiveness of liposomes in delivering essential nutrients and medicines like CBD in the body. Liposomes are water-soluble and fat-soluble. These unique features aid in providing molecules in liposomes like CBD to the intended destinations without any degradation.

Related: Water Soluble CBD Products. All You Need To Know

Dr Rae argues that continuous studies of the liposomal delivery system and CBD have improved the liposomal effectiveness and bioavailability. This, in turn, enhances the absorption rate of medicines and nutrients in the human bloodstream. Besides, improved liposomal bioavailability aids in the movement of CBD in tissues, cells and body organs; thus, consumers get the desired benefits from their CBD.

Design on liposomes

What is Bioavailability?

In order to understand the advantages of liposomal delivery, you must understand the concept of bioavailability. Bioavailability denotes the extent to which a nutrient or a drug is available to be used in the anticipated biological destination. Bioavailability varies depending on how one consumes a constituent. For example, administration through the veins provides a hundred per cent bioavailability. This is essential when nurses and doctors are administering drugs and nutrients like CBD to patients.

CBD formulations that are administered through the mouth are very common. However, these formulations have quite a lower bioavailability compared to inhaled CBD formulations. This is because most of the oral CBD is wasted in the digestive system resulting in less than nine per cent bioavailability.

However, liposomal products aids in protecting the CBD from digestive enzymes in the digestive tract. According to Endocannabinoid Medicine journal, all patients who took liposomal CBD oil orally had it in their bloodstream after an hour. Contrary, only 40% of patients who took standard CBD oil had it in their blood after an hour.

Advantages of Liposomal CBD

Liposomal delivery increases bioavailability. This is the primary and most crucial feature of liposomal delivery. Liposomes protect the CBD, ensuring they remain complete as they reach body tissues and cells.

By this, the CBD is protected from digestive enzymes that would damage them. This, in turn, increases bioavailability three times more. Additionally, the CBD becomes more effective and works at a faster rate meaning you may use little and get the maximum effect.

As bioavailability increases, the body absorbs more CBD, thus utilizes all its benefits. Liposomal CBD oil is cost-effective compared to non-liposomal CBD. This is because its less concentration and usage yields long-lasting effects.

Liposomal CBD

Can we Say Liposomal CBD is Better than other kinds of CBD?

As much as we have seen that liposomal delivery offers excellent benefits, they are not nearly better than other CBD. Liposomal CBD may be expensive compared to other CBD products; therefore, people may end up not using them. CBD oil plays an important role in vitamins consumption. CBD oil is important in our body. However, there are other CBD products apart from CBD oil which are equally important.

As much as the effectiveness of 20g liposomal product compares to 50g of regular CBD, you may opt to go for the 50g if the 20g is more expensive. The only advantage would be to use less for the same effect of using more of the regular product. However, in the end, you get the same results since all of them contain CBD.

New developments in CBD delivery systems are making CBD delivery more complicated. Initial CBD products like gummies, oral tinctures and oils are outperformed by developing technologies like nano-emulsified CBD. These are tinier molecules, which in theory are more effective compared to liposomes thus make the delivery systems more effective. Tiny molecules mean a high degree of absorption due to the large surface area relating to body tissues and enzymes.

The main objective of manufacturing Nanoemulsions is to increase delivery of lively medicinal compounds like CBD. There are fewer nanoemulsion products and CBD in the market currently. Research suggests that these products offer satisfying results due to increase bioavailability. However, being small does not make them better than other CBD.

Dr Rae suggests that there are unidentified risks relating to nanoparticles in general like nano CBD. During the preparation of these particles, some ingredients become harmful when made super tiny. However, if these ingredients remain in their initial state, they are safe to use. There are other products like vitamins that benefit from CBD liposomes. The same way CBD liposomes work in CBD also works in this vitamins.

Are Liposomes Dangerous?

According to research, liposomes are safe to use. In fact, they enhance the bioavailability, allow excellent control and limit the toxicity of CBD. Since they are thought to be safe in delivering products like CBD, experts continue to research them to identify the unique properties lysosomes, especially in CBD. However, the product has complex physics and chemistry, especially in its delivery system. Therefore, it should be handled with care and expert knowledge from qualified medicinal chemists and not average hemp oil extraction company.

Furthermore, hemp oil extraction companies need to adhere to set regulations and deliver quality CBD and hemp oil products. Both CBD oil and hemp oil are special and should be handled with care

Despite liposomal packaging being safe in a particular drug, it may be toxic in a different type of medication. All drugs, including liposomal, should be studied thoroughly before they enter the market. Experts should make sure the drugs are safe to be used by living things.

Besides, drugs should perform the intended purposes. Therefore, trials must first be conducted and even if it takes years to release a drug to the market, it must meet all the necessary qualifications. When you go to the market, ensure you purchase a liposomal product like CBD that contains published safety data.

There is scarce research on the safety of liposomal formulations. Both small-scale and large-scale studies are undergoing to come up with more safety information. In a current safety study relating to liposomal CBD, no patient experienced dangerous effects on kidney function, blood sugar levels, liver function or fluid balance and electrolyte.

Reseach on liposomes includes:

People whose blood measures ranged from low to high were not affected by this kind of CBD oil. Surprisingly, people with high glucose levels in their body were able to bring it back to normal after taking liposomal CBD treatment for a month. Although the results are based on a small population, it was concluded that liposomal CBD is safe to use.


Sercombe, L., Veerati, T., Moheimani, F., Wu, S. Y., Sood, A. K., & Hua, S. (2015). Advances and Challenges of Liposome Assisted Drug Delivery. Frontiers in pharmacology6, 286. https://doi.org/10.3389/fphar.2015.00286

Bangham A.D., Standish M.M., Weissmann G. (1965). Diffusion of univalent ions across the lamellae of swollen phospholipids. J. Mol. Biol, 13:238–252. doi: 10.1016/S0022-2836(65)80093-6.

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